The Birthplace of John Wayne is Easy to Find!

From Interstate 80:

Take Exit 110 (US Highway 169) south through DeSoto and follow it approximately 14 miles into Winterset, where it becomes John Wayne Drive. Stay on John Wayne Drive until you reach South Street. Turn left (east) 1 block to the Birthplace (just follow the signs!)

From Interstate 35:

Take Exit 56 (State Highway 92) west approximately 14 miles to the junction with U.S. 169 in Winterset. Turn left (south); the road becomes John Wayne Drive. Follow it until you reach South Street. Turn left (east) 1 block to the Birthplace (just follow the signs!)